Akriderm Ghent ointment 15g tube

$6.39

Akriderm Ghent ointment 15g tube

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SKU: 2087088462 Categories: , , Tags: ,

Description

Composition
Active substance:
100 g of ointment contains: betamethasone dipropionate in terms of 100% substance – 0,064 g, equivalent to 0.05 g of betamethasone, gentamicin sulfate equivalent to Gentamicin – 0.1 g ;.
Excipients:
Propyl (Nipasol) – 0.05 g, liquid paraffin (vaseline oil) – 5 g isopropyl – 1 g Petrolatum – 100 g
Description:
Translucent ointment white or nearly white.
Product form:
Ointment for external use 0.05% + 0.1%. 15 and 30 g in a tube of aluminum. Each tube together with instructions for use in a stack of cardboard.
Contraindications
Hypersensitivity to betamethasone, gentamicin or any of the excipients included in the formulation.
Lupus, vaccines, viral skin infections, perioral dermatitis, rosacea.
Cutaneous manifestations of syphilis, skin post-vaccination reactions infancy (up to 2 years).
Dosage
0.64 mg + 1 mg / g
Indications
Dermatitis (simple and allergic), particularly secondarily infected, eczema (atopic, children, nummular), atopic dermatitis (neurodermatitis diffuse), simple chronic zoster (restricted neurodermatitis), solar dermatitis, exfoliative dermatitis, radiation dermatitis, diaper rash, psoriasis, pruritus.
Interaction with other drugs
Drug interactions with other drugs is not revealed.
Overdose
Symptoms: Prolonged use of local corticosteroids in high doses may suppress adrenal function with the development of secondary adrenal insufficiency and Cushing’s symptoms, including Cushing’s syndrome.
When a single overdose of gentamicin showing any symptoms is not expected.
Prolonged treatment with gentamycin at high doses can lead to growth insensitive flora.
Treatment: Symptomatic. Acute symptoms of Cushing’s usually reversible. electrolyte balance correction is carried out if necessary.
pharmachologic effect
Pharmacological group:
Glucocorticosteroids for local use + aminoglycoside antibiotic.
Pharmacodynamics:
Anti-inflammatory, antiallergic, antipruritic, antibacterial agent. Betamethasone dipropionate – synthetic glucocorticosteroid (GCS) okazyvayuschiyprotivovospalitelnoe, antiallergic, antipruritic and sosudosuzhivayuscheedeystvie. When applied topically, constricts blood vessels, reduces itching, reduces inflammation vydeleniemediatorov (of eosinophils and mast cells), interleukins 1 and 2,
gamma interferon (from lymphocytes and macrophages), inhibits the activity of hyaluronidase iponizhaet vascular permeability. Spetsificheskimiretseptorami interacts with cytoplasmic cells stimulates the synthesis of mRNA, inducing the formation of proteins, including lipocortin mediating cellular effects. Lipokortin inhibits phospholipase A2 block the release of arachidonic acid biosynthesis endoperekisey, prostaglandins, leukotrienes (contributing to the development of inflammation, allergy and other pathologic processes) .Gentamitsin – broad spectrum antibiotic aminoglycoside. It has a bactericidal action and provides a highly efficient local treatment of primary and secondary bacterial infections of skin. Active against gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; and Gram-positive bacteria: Streptococcus spp. (Sensitive strains of alpha- and beta-hemolytic group A streptococcus), Staphylococcus aureus (coagulase positive, coagulase strains and some strains producing penicillinase).
Pharmacokinetics:
When applied topically the drug at therapeutic doses transdermal absorption of active ingredients in the blood is very small.
The use of occlusive dressings improves absorption of betamethasone and gentamicin, which can lead to increased risk of systemic side effects.
Pregnancy and breast-feeding
topical glucocorticosteroids safety in pregnant women has not been established; prescription drugs of this group during the period of pregnancy is justified only if the potential benefit to the mother outweighs the potential risk to the fetus. During pregnancy, this group of drugs should not be used in high doses or for long periods.
Not known whether the drug passes into breast milk, therefore it is necessary to abandon breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Very rarely, when applying ointment Akriderm® Gent says: burning sensation, erythema, exudation, pigmentation disorders and itch.
Side reactions occurring under the application of local glucocorticosteroids (especially when using occlusive dressings): burning sensation, itching, dryness, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, secondary infection, skin atrophy, striae , sudamen.
Extremely rare (in cases of significant systemic absorption gentamicin) there is a risk of damage of the auditory nerve and the vestibular apparatus, accompanied by tinnitus and impaired hearing. Such side effects are developed in cases when patients are simultaneously taking ototoxic or nephrotoxic drugs and impaired renal function.
Prolonged treatment or application to large surface – the development of systemic side effects of corticosteroids: weight gain, osteoporosis, hypertension, edema, ulceration of the mucosa of the gastrointestinal tract, exacerbation of latent infection foci, hyperglycemia, agitation, insomnia, menstrual irregularities.
The children – the oppression of the hypothalamus-pituitary-adrenal system, Cushing’s syndrome, growth retardation, retarded weight gain, increased intracranial pressure (betamethasone).
special instructions
Ointment Akriderm® Gent is not recommended for use on facial skin and scalp.
We do not recommend the use of ointments under occlusive dressing, except in cases when it is necessary.
Should not enter Gent Akriderm® ointment in the eye and periorbital region.
Gent Akriderm® ointment for external application is not to be used for treating varicose venous leg ulcers and open wounds.
Prolonged application of the ointment Akriderm® Gent on large surfaces with impaired skin integrity potential exists suction and gentamicin, respectively, of ototoxicity symptoms.
Some areas of the body (inguinal folds, armpits and perianal region) are more exposed to risk of stretch marks. Therefore, the duration of the drug in these areas of the body must be limited.
In cases of fungal superinfection requires additional use of an antifungal drug.
The effect on the ability of control of vehicles and mechanisms
Data on the adverse effects of the drug on the ability to drive and there are no mechanisms.
Storage conditions
At a temperature of 15 to 25 C.
Keep out of the reach of children.
Dosing and Administration
Adults. The ointment is applied a thin layer to the affected skin area and the surrounding tissue 2 twice a day (morning and evening), lightly rubbing in a circular motion. In the area of ​​skin with a thicker epidermis and in the places with which the drug is easily eliminated (hands and feet), the ointment should be applied more often. The duration of treatment depends on the efficacy and tolerability of therapy, and is generally no more than 2-4 weeks.
Children. Permitted use of the drug for children from two years only on strict conditions and under the supervision of a physician. Due to the fact that children skin area relative to body weight is greater and the epidermis is not sufficiently developed, when used topically drug may absorption proportionally more active ingredients and, consequently, there is a greater risk of systemic side effects. Use the drug in children should be as soon as possible and in compliance with all safety measures.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

QUINACRINE

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