Aflyudol tab 50mg 20 pc

Description

Composition
Active substance:
1 tablet contains: umifenovir hydrochloride monohydrate in terms of umifenovir hydrochloride – 50 mg or 100 mg.
Excipients:
Lactose monohydrate, povidone K-25 (polyvinyl pyrrolidone of middle), crospovidone, colloidal silicon dioxide (Aerosil), magnesium stearate.
Excipients shell: Opadry II White [lactose monohydrate – 36%, hypromellose – 28% titanium dioxide – 26%, macrogol 4000 (polyethylene glycol 4000) – 10%].
Description:
Round biconvex tablets covered with a foil cover from white to white with cream tint colors, rough, on the fracture from white to white to greenish or yellowish cream color.
Product form:
Tablets, coated membrane sheath 50 mg or 100 mg. 10 tablets in blisters. 1, 2, 4 blisters together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to umifenovir or any component of the drug, lactose deficiency, lactose intolerance, glucose-galactose malabsorption, children up to 3 years.
Dosage
50 mg
Indications
Prevention and treatment in adults and children: influenza A and B, and other acute respiratory viral infections.
Combined therapy of chronic bronchitis, pneumonia, and recurrent herpetic infection. Prevention of postoperative infectious complications.
Interaction with other drugs
In the appointment of other drugs, negative effects were noted.
Overdose
It is not checked.
pharmachologic effect
Pharmacological group:
An antiviral agent.
Pharmacodynamics:
An antiviral agent. Specifically inhibits the influenza viruses A and B, coronavirus associated with severe acute respiratory syndrome (SARS). According to the mechanism of the antiviral action relates to inhibitors of fusion (fusion), interacts with hemagglutinin of the virus and prevent fusion of lipid shell of a virus and cellular membranes. It has moderate immunomodulatory effects. Possesses interferon-inducing activity, stimulating humoral and cellular immune response, the phagocytic function of macrophages, increases resistance to viral infections. Reduces the incidence of complications associated with viral infection, as well as exacerbation of chronic bacterial diseases.
Therapeutic efficacy for viral infections manifest in reducing the severity of intoxication and clinical phenomena, reduction of duration of the disease, reducing the risk of complications.
It refers to preparations of low toxicity (LD50> 4 g / kg). It does not have any negative impact on the human body when administered orally in the recommended dosages.
Pharmacokinetics:
Absorption – fast. Rapidly distributed to organs and tissues. Time to maximum concentration when taking a dose of 50 mg – 1.2 hours at a dose of 100 mg -. 1.5 h metabolized in the liver. The half-life is 17-21 h. About 40% is excreted unchanged, primarily in the bile (38.9%) and the minor kidneys (0.12%). During the first day shows 90% of the administered dose.
Conditions of supply of pharmacies
Without recipe.
side effects
Rarely – allergic reactions.
special instructions
Shows no central neurotropic activity and can be used in medical practice as a preventive measure in healthy persons of various professions, including those requiring special attention and coordination of movements (transport drivers, operators, etc.).
Storage conditions
Store at a temperature not higher than 25 C. Keep out of reach of children.
Dosing and Administration
Inside. Before meals.
Single dose: 3 to 6 years 50 mg, from 6 to 12 years 100 mg, with 12 mg-200.
Dosing regimen.
Nonspecific prevention during influenza epidemics and ARI in single-dose 2 times a week for 3 weeks.
Nonspecific prevention of direct contact with patients with influenza and other SARS-1 in a single dose once a day for 10-14 days.
Treatment of influenza and ARI in single-dose 4 times a day (every 6 hours) for 5 days.
Combined therapy of chronic bronchitis, pneumonia and recurrent herpes infection in a single dose, 4 times a day (every 6 hours) for 5-7 days, then a single dose 2 times a week for 4 weeks.
Prevention of postoperative infectious complications, in a single dose up to 2 days prior to surgery, then at 2 and 5 days after surgery.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist