Advantan oily ointment for naruzhn.prim-I 0.1% 15g tube

$11.85

Advantan oily ointment for naruzhn.prim-I 0.1% 15g tube

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SKU: 01520631938 Categories: , , Tags: ,

Description

Composition
Active substance:
1 g of ointment (fatty) comprises – methylprednisolone aceponate 0.001 g
Excipients:
White soft paraffin, liquid paraffin, microcrystalline wax, hydrogenated castor oil.
Description:
White or slightly yellowish translucent greasy ointment.
Product form:
Ointment for external application (fat) 0.1% 5, 10, 15, 20, 25, 30, and 50 g of aluminum laminated polyethylene tube, sealed with a membrane, with a plastic screw-on cap. The tube together with instructions for use placed in a cardboard box.
Contraindications
– tuberculous or syphilitic processes in applying the product; – viral diseases (e.g., chicken pox, shingles), in applying the product; – rosacea, perioral dermatitis in applying the product; – Children up to age of 4 months; – skin areas with manifestations response to vaccination; – hypersensitivity to the drug.
Dosage
1 mg / g
Indications
Inflammatory skin diseases which are sensitive to therapy with topical corticosteroids: – atopic dermatitis, atopic dermatitis, infantile eczema; – true eczema; – microbial eczema; – occupational eczema; – simple contact dermatitis; – allergic (contact) dermatitis; – disgidroticheskaya eczema.
Interaction with other drugs
Not found.
Overdose
The study of acute toxicity methylprednisolone aceponate not revealed any risk of acute toxicity at a single cutaneous excessive use (applying the preparation on a large area under conditions favorable for absorption) or Accidental ingestion.
When excessively long and / or vigorous application of glucocorticosteroids may develop skin atrophy (thinning of the skin, telangiectasia, striae).
When the atrophy of the drug should be abolished.
pharmachologic effect
Pharmacological group:
Glucocorticosteroids for local use.
Pharmacological properties:
The active drug component Advantan – methylprednisolone aceponate – represents a non-halogenated steroid.
Pharmacodynamics:
When applied topically Advantan suppresses inflammatory and allergic skin reactions as well as reactions associated with enhanced proliferation, leading to reduced inflammation objective symptoms (erythema, edema, oozing, etc.) and subjective sensations (itching, irritation, pain and etc.). In the application of methylprednisolone aceponate externally at the recommended dose, systemic exposure is minimal in both humans and animals. After repeated deposition Advantan large surfaces (40-60% of the surface of the skin), and the application under an occlusive dressing is not marked disorders of the adrenal 2: cortisol plasma level and its circadian rhythm remain within the normal range, reducing cortisol level in daily urine occurs . In clinical studies, the application of Advantan to 12 weeks in adults and 4 weeks in children (including young children) there was no evidence of skin atrophy, telangiectasia, striae and acne-like rash. Methylprednisolone aceponate (particularly, its major metabolite – 6-alpha-17-propionate metilprednizolon-) binds to intracellular receptors glucocorticosteroid. The steroid-receptor complex binds to certain regions of the DNA of cells of the immune response, thus causing a series of biological effects. In particular, binding of the steroid-receptor complex to DNA by cells of the immune response leads to the induction of synthesis macrocortin. Macrocortin inhibits the release of arachidonic acid and, thus, the formation of inflammatory mediators type prostaglandins and leukotrienes. Inhibition of glucocorticoid synthesis of prostaglandins vasodilating and vasoconstrictive effect of epinephrine potentiation lead to vasoconstrictor effect.
Pharmacokinetics:
Methylprednisolone aceponate is hydrolyzed in the epidermis and dermis. The main and most active metabolite is 6-alpha-methylprednisolone-17-propionate, having a much higher affinity to glucocorticoid receptors in the skin that indicates the presence of its “bioactivation” of the skin. Degree of percutaneous absorption is dependent on the skin, the formulation and application method (with or without occlusive dressing). Percutaneous absorption in children and adults with atopic dermatitis (neurodermatitis), psoriasis and was not more than 2.5%, only slightly higher than in healthy volunteers (0.5-1.5%). After entering the systemic circulation of 6-alpha-methylprednisolone-17-propionate is rapidly conjugated with glucuronic acid, and thus, in the form of 6-alpha-methylprednisolone 17-propionate glucuronide inactivated. Metabolites methylprednisolone aceponate eliminated primarily by the kidneys with a half-life of about 16 hours. Methylprednisolone aceponate and its metabolites are not cumulated in the body.
Pregnancy and breast-feeding
If necessary, use an ointment (fat) Advantan during pregnancy and lactation should carefully weigh the potential risk to the fetus and the expected treatment benefit to the mother. These periods are not recommended for prolonged use of the drug on extensive skin surfaces. Nursing mothers should not be applied in the preparation of the mammary glands.
Conditions of supply of pharmacies
Leave without a doctor’s prescription.
side effects
Usually the drug is well tolerated.
Very rare (less than 0.01% of cases), local reactions can occur, such as itching, burning, erythema, vesicular rash. If the drug is used for more than 4 weeks and / or the area of ​​10% or more of the body surface, the following reaction may occur: skin atrophy, telangiectasia, striae, akneformnye skin lesions, systemic effects due to absorption of the corticosteroid. In clinical studies, none of these side effects were not observed in the application of a fatty ointment Advantan to 12 weeks in adults and 4 weeks in children.
In rare cases (0.01% – 0.1%) could be observed folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, allergic reactions to a component of the drug.
special instructions
In the presence of bacterial complications, and / or in addition to dermatomycosis Advantanom therapy is necessary to carry out a specific antibacterial and / or antimycotic treatment. Avoid getting product in eyes. As in the case of systemic corticosteroids after topical use of corticosteroids may develop glaucoma (e.g., when using very large doses or prolonged use of occlusive dressings, or application to the skin around the eyes).
Effects on ability to drive vehicles, machinery – have been identified.
Storage conditions
Store at a temperature not higher than 30 degrees Celsius.
Keep out of the reach of children.
Dosing and Administration
Outwardly. Adults and children from 4 months of age. The drug is applied 1 time a day a thin layer to the affected skin.
Typically, the duration of continuous daily treatment Advantanom should not exceed 12 weeks for adults and 4 weeks for children.
For the treatment of long-term chronic inflammatory processes in the skin is very dry skin need anhydrous formulation. Occlusive fatty ointment Advantan effect provides a pronounced therapeutic effect even at a considerable infiltration and lichenification.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Advantan

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