Advantan cream appearance. 0.1% 15g tuba

$11.80

Advantan cream appearance. 0.1% 15g tuba

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SKU: 02091337914 Categories: , , Tags: ,

Description

Composition
Active substance:
Methylprednisolone aceponate 1 mg.
Excipients:
Decyl oleate – 100 mg, 40-55% glyceryl monostearate – 85 mg, cetostearyl alcohol (60% cetyl alcohol, stearyl alcohol 40%) – 25 mg solid fat – 25 mg, 378 softizan – 75 mg, macrogol stearate – 30 mg, glycerol 85% – 50 mg disodium edetate – 1 mg, benzyl alcohol – 10 mg, butylhydroxytoluene – 60 mcg purified water – 597.94 mg.
Description:
Cream for external use of white or yellowish, opaque.
Contraindications
– tuberculous or syphilitic processes in applying the product;
– viral diseases in the field of application of the drug (e.g., varicella, herpes zoster);
– rosacea, perioral dermatitis in applying the product;
– skin areas with pryavleniyami response to vaccination;
– Children up to age 4 months;
– hypersensitivity to the drug.
Dosage
1 mg / g
Indications
Inflammatory skin diseases, sensitive to treatment with topical corticosteroids:
– atopic dermatitis, neurodermatitis, infant eczema;
– true eczema;
– microbial eczema;
– occupational eczema;
– disgidroticheskaya eczema;
– simple contact dermatitis;
– allergic (contact) dermatitis.
Interaction with other drugs
Drug interaction Advantan® drug is not revealed.
Overdose
The study of acute toxicity methylprednisolone aceponate not revealed any risk of acute toxicity at a single excessive external application (application of the drug over a large area under conditions favorable for absorption) or Accidental ingestion.
Symptoms: excessively long and / or intensive topical application of corticosteroids may develop skin atrophy (thinning of the skin, telangiectasia, striae).
When the manifestation of atrophy of the drug should be abolished.
pharmachologic effect
Pharmacological group:
Glucocorticosteroids for local use.
Pharmacological properties:
When applied topically Advantan® suppresses inflammatory and allergic skin reactions as well as reactions associated with enhanced proliferation, which leads to a decrease in objective signs of inflammation (including erythema, edema, oozing, and so on. D.) And subjective sensations ( including itching, irritation, pain, and so on. d.).
When applied topically methylprednisolone aceponate at the recommended dose of the systemic effect expressed minimally in both humans and animals. After repeated deposition Advantan large surfaces (40-60% of the skin surface), as well as in the application under an occlusive dressing is not marked disorders of adrenal function: cortisol plasma level and its circadian rhythm remain within the normal range, reducing cortisol level in daily urine not It is happening.
In clinical studies, the application of Advantan to 12 weeks in adults and 4 weeks in children (including young children) there was no evidence of skin atrophy, telangiectasia, striae and acne-like rash.
Methylprednisolone aceponate (particularly its major metabolite – 6-alpha-methylprednisolone 17-propionate) binds to the intracellular glucocorticoid receptor. The steroid-receptor complex binds to certain regions of the DNA of cells of the immune response, thus causing a series of biological effects.
In particular, the binding of a steroid receptor complex to the DNA of cells of the immune response leads to the induction of synthesis macrocortin. Macrocortin inhibits the release of arachidonic acid and, thus, the formation of inflammatory mediators type prostaglandins and leukotrienes.
Inhibition of GCS vasodilating synthesis of prostaglandins and potentiation vasoconstrictive effect of epinephrine leads to a vasoconstrictor effect.
Pharmacokinetics.
Pharmacokinetics:
Suction
Degree of percutaneous absorption is dependent on the skin, the formulation and application method (with or without occlusive dressing). In the application of ointments, creams or fatty ointments, percutaneous absorption in children and adults with atopic dermatitis (neurodermatitis), psoriasis and it was not more than 2.5%, only slightly higher than in healthy volunteers (0.5-1.5%).
In applying the drug was very low (0.27%) in the form of an intensity of absorption through the skin with artificial inflammation that is only slightly higher than healthy skin (0.17%). In the case of treatment of the whole body (such as sunburn) systemic dose is about 4 mg / kg body weight / day, which excludes systemic effects.
Metabolism and excretion
Methylprednisolone aceponate is hydrolyzed in the epidermis and dermis. The main and most active metabolite is 6-alpha-methylprednisolone 17-propionate, having a much higher affinity to glucocorticoid receptors in the skin, which indicates its presence in the bioactivation skin.
After entering the systemic circulation 6-alpha-methylprednisolone 17-propionate rapidly it conjugated with glucuronic acid, and thus, in the form of 6-alpha-methylprednisolone 17-propionate glucuronide inactivated.
Metabolites methylprednisolone aceponate eliminated primarily by the kidneys, T1 / 2 – about 16 hours.
Methylprednisolone aceponate and its metabolites do not cumulate in the organism.
Pregnancy and breast-feeding
If necessary, use Advantan® during pregnancy and lactation should carefully weigh the potential risk to the fetus and potential benefits of therapy for the mother. These periods are not recommended for prolonged use of the drug on extensive skin surfaces.
Nursing mothers should not be applied in the preparation of the mammary glands.
Use in children
Continuous daily application Advantan in the form of a cream, ointment or fatty ointment for adults is not more than 12 weeks, for children – are not more than 4 weeks.
Is contraindicated in children younger than 4 months.
Conditions of supply of pharmacies
The drug is approved for use as a means of OTC.
side effects
Usually the drug is well tolerated.
Very rarely (less than 0.01% of the cases), local reactions can occur, such as itching, burning, erythema, vesicular rash. If the drug is used up to 4 weeks and / or the area of ​​10% or more of the body surface, the following reaction may occur: skin atrophy, telangiectasia, striae, akneformnye skin lesions, systemic effects due to absorption of the corticosteroid. In clinical studies, none of these side effects were not observed when using the drug Advantan® to 12 weeks in adults and 4 weeks in children.
In rare cases (0.01-0.1%) can be observed folliculitis, hypertrichosis, perioral dermatitis, skin depigmentation, allergic reactions to a component of the drug.
special instructions
In the presence of bacterial complications, and / or tinea in addition to drug therapy Advantan® necessary to carry out a specific antibacterial or antifungal treatment.
Avoid getting product in eyes.
As in the case of systemic corticosteroids after topical application of corticosteroids may develop glaucoma (e.g., when using very large doses or prolonged use of occlusive dressings, or application to the skin around the eyes).
Effects on ability to drive vehicles and management mechanisms
Not found.
Storage conditions
Store at a temperature not higher than 25 ° C. out of reach of children.
Dosing and Administration
Outwardly.
Adults and children 4 months of drug applied 1 time / day thin layer to the affected skin.
Continuous Advantan daily application in the form of a cream, ointment or fatty ointment should not exceed 12 weeks for adults, for children – 4 weeks. Advantanom course of treatment in the form of emulsions usually should not exceed 2 weeks.
Cream is a dosage form with low fat content and a high water content, so it is recommended in subacute and acute inflammation without significant soak. The cream provides elimination of inflammation as smooth skin and on the scalp, including skin prone to fat.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Advantan

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