Advanced Calcemin, calcium complex, vitamin D3 and minerals tablet 60 pcs., Bayer

$13.87

Advanced Calcemin, calcium complex, vitamin D3 and minerals tablet 60 pcs., Bayer

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Description

Composition
Active substance:
1 tablet contains – Calcium (calcium citrate tetrahydrate and calcium carbonate) 500 mg Vitamin D3 (Kolekaltsiferol) 200 IU, magnesium (magnesium oxide) 40 mg of zinc (zinc oxide) 7.5 mg copper (copper oxide) 1 mg, manganese (manganese sulfate) 1.8 mg, boron (sodium borate decahydrate) 250 mcg.
Excipients:
Maltodextrin, microcrystalline cellulose, croscarmellose sodium, stearic acid, soy polysaccharide, sodium lauryl sulfate.
Sheath: hypromellose, titanium dioxide, magnesium silicate, triacetin, a mineral oil, aluminum lake dye-based red amazing (Red № 40 Aluminum Lake Dye sunset yellow (Yellow № 6), aluminum lake dye Brilliant Blue (Blue № 1).
Oval biconvex tablets, film-coated with a pink line on one side.
Description:
Calcemin Advans-
The complex of calcium, vitamin D3 and minerals.
Calcemin Advance (1) is a drug with enhanced by formula (2), which contains vitamin D3 and minerals for the prevention of bone fragility and complex treatment of osteoporosis. With age, calcium leached from the bones and they become brittle.
Unlike other calcium preparations (3) Advance Calcemin contains special minerals (magnesium, zinc, manganese, copper, boron) for the formation of a collagen mesh, which holds the calcium in bone, preventing its leaching (4).
Advanced Calcemin apply:
– for the prevention and treatment of osteoporosis complex;
– for Improved fracture healing;
– to make up for calcium deficiency and mikroelementovKaltsemin Advance – to the bones remain strong!
(1). There are contraindications. Before use, contact the person.
(2). compared with the drug Calcemin
(3). Under ATC: A12AX (calcium preparations in combination with other drugs)
(4). Gromova OA, Torshin IY et al. Calcium and collagen biosynthesis: a systematic analysis of the molecular mechanisms of action // Russian Journal of Medicine. 2016. 15. C. number 10091017. ”
Product form:
Tablets, film-coated.
30, 60 and 120 tablets in a bottle of high-density polyethylene having a screw cap of high density polyethylene, sealed plastic film. The neck of the vial is sealed protective packaging foil. The vial together with instructions for medical use of the drug is placed in a cardboard box.
Contraindications
Increased individual sensitivity to the drug, vitamin hypervitaminosis D; hypercalcemia and / or conditions resulting in hypercalcaemia such as sarcoidosis, malignant tumor and primary hyperthyroidism; hypercalciuria, renal failure, urolithiasis, nephrolithiasis, active form of tuberculosis, children’s age (12 years); allergic to peanut oil and soybean, as the drug enters soy polysaccharide.
Carefully:
During pregnancy and lactation, renal insufficiency.
Indications
For the prevention of and in combination for the treatment of osteoporosis of various genesis: age, women in menopause (natural or surgical), idiopathic, in people receiving long-term steroids and immunosuppressants; as well as the teeth and periodontal diseases and others.
In situations requiring additional calcium intake, vitamin D and minerals (e.g., to increase the consolidation of traumatic fractures, during pregnancy, and malnutrition al.).
Prevention and treatment of calcium deficiency, vitamin D, magnesium, zinc, copper, manganese and boron.
Interaction with other drugs
The calcium salt:
Calcium salts may interact with many substances due to changes in gastric pH, effect on gastric emptying or formation of complexes with certain substances, which leads to reduction of both substances suction. Since these interactions occur in the gastrointestinal tract, to minimize the possibility of interaction of calcium supplements to be taken separately from other medicaments. It is usually sufficient compliance interval between drug administration, at least for 2 hours before or 4-6 hours after administration of the preparation of calcium, unless indicated otherwise.
Antibiotics and antivirals (e.g., tetracyclines, fluoroquinolones):
Calcium tetracycline antibiotics decreases absorption by forming insoluble complexes. Patients should take these drugs for at least two hours before or 4 to 6 hours after ingestion of the calcium preparation.
levothyroxine:
Calcium reduces the absorption of levothyroxine, probably due to formation of insoluble complexes. Patients should take levothyroxine, at least for 4 hours before or 4 hours after ingestion of calcium supplements.
Phosphates, bisphosphonates and fluorides:
Calcium reduce the absorption of bisphosphonates. Patients should take bisphosphonates, at least 30 minutes before the application of calcium, but preferably at different times.
Eltrombopag:
There was a decrease in plasma level eltrombopaga 59% at breakfast consumption with high fat and high in calcium (427 mg), while food with low level of calcium (
Sodium fluoride:
Calcium absorption degrade sodium fluoride. Patients should take sodium fluoride, at least for 2 hours before or 2 hours after administration of calcium preparations.
Cardiac glycosides and calcium channel blockers:
Hypercalcemia increases the likelihood of cardiac arrhythmias fatal when applying cardiac glycosides such as digoxin and reduces the effectiveness of calcium channel blockers such as verapamil in atrial fibrillation. It is recommended to monitor blood serum calcium levels in people taking calcium and / or vitamin D and these drugs simultaneously.
Protease inhibitor:
If products containing calcium or magnesium, including buffered preparations are administered together with certain protease inhibitors may reduce plasma concentrations of these substances. It is therefore recommended to use a protease inhibitor for 2 hours before or 1 hour after taking the preparations containing aluminum, calcium or magnesium. This effect was seen with the following medications: amprenavir, atazanavir, and tipranavir.
Thiazide diuretics:
Thiazide diuretics decrease calcium excretion. Due to increased risk of hypercalcaemia, should regularly monitor the blood serum calcium levels during concomitant use of thiazide diuretics.
Some drugs may reduce vitamin gastrointestinal absorption of D. In order to minimize this interaction need separate use of these agents and vitamin D, at least 2 hours before or 4-6 hours after administration of vitamin D. To these drugs include: ion exchange resins (e.g., cholestyramine), a laxative, orlistat, carbamazepine, phenytoin and barbiturates increase the conversion of vitamin D to its inactive metabolite, reducing the effect of vitamin D3.
Interaction with food:
Oxalic acid, phytic acid. Oxalic acid, which is in spinach and rhubarb, and phytic acid, which is in cereals may inhibit calcium absorption. Not to take calcium supplements within 2 hours after ingestion of a meal containing a high concentration of oxalic and phytic acid.
Iron, zinc, magnesium:
Calcium can reduce the absorption of dietary iron, zinc and magnesium. However, in people with normal security these minerals it has no clinical significance in the long term. Patients at risk for iron deficiency, zinc or magnesium should take calcium supplements at bedtime, and not in the meal time to avoid slowing down the absorption of trace elements.
Alimentary fiber:
Some components of dietary fiber can slow the absorption of calcium. These include phytic acid (found in wheat bran), oxalic acid (contained in spinach and rhubarb) and uronic acid (a common component of plant fiber).
Overdose
Hypervitaminosis of vitamin D3, hypercalcemia and hypercalciuria.
Symptoms: thirst, polyuria, decreased appetite, constipation, nausea, vomiting, dizziness, muscle weakness, headache, fainting, coma, fatigue, bone pain, mental disorders, nephrocalcinosis, abdominal pain, kidney stones, in severe cases, – cardiac arrhythmias.
With prolonged use at doses greater than 2500 mg of calcium – kidney damage, calcification of soft tissues.
In the case of detecting the first signs of overdosing is necessary to reduce the dose or stop using the product, contact your doctor.
In case hypercalciuria exceeding 7.5 mmol / day (300 mg / day), it is necessary to reduce the dosage or discontinue taking the drug.
Treatment: rehydration, the use of loop diuretics (e.g., furosemide), glucocorticoids, calcitonin, bisphosphonates, in severe cases hemodialysis.
In case of accidental overdose, induce vomiting, gastric lavage. Symptomatic therapy.
pharmachologic effect
Pharmacological group:
Calcium-phosphorus metabolism regulator.
Pharmacological properties:
Combined preparation containing vitamins, micro- and macrocells; effect due to the properties included in the ingredients.
Calcium is involved in the formation of bone tissue, reduces bone resorption (resorption) and increases bone density, prevents diseases of the musculoskeletal system, helps to strengthen the skeletal system and joints.
Calcium citrate provides the absorption of calcium, regardless of the functional state of the gastrointestinal tract, is useful for treating patients with reduced secretory function of the digestive tract, as well as during treatment with drugs to lower the secretion; reduces bone resorption markers of bone, indicating a slowing of the destruction of the bone tissue; It adjusts the level of parathyroid hormone, which leads to an improvement in the regulation of calcium homeostasis; oxalate does not increase the calcium content in urine and consequently does not cause a risk of stone formation in the kidneys; It does not block the absorption of iron, which reduces the risk of developing iron deficiency anemia.
Kolekaltsiferol (vitamin D3) regulates calcium and phosphorus metabolism in the body, is involved in forming the skeleton, contributes to the preservation of bone structure, increases calcium absorption in the intestine and reabsorption of phosphorus in the kidney tubules.
Magnesium is involved in the formation of bone and muscular tissue, and is also involved in protein synthesis (including collagen type I).
Zinc and magnesium are needed for the synthesis of organic bone matrix.
Zinc promotes the synthesis of sex hormones that prevent the destruction of the bone tissue.
A positive effect on bone density.
Manganese is involved in the formation of proteoglycans, which improves the quality of bone tissue and forms a protein (collagen) matrix of bone tissue.
Copper is involved in the synthesis of collagen and elastin, a component of bone and connective tissue, which affects the processes of bone mass.
Boron reduces the excessive activity of parathyroid hormone, improves calcium absorption, reduces the risk of kolekaltsiferola deficit, it helps prevent osteoporosis.
Pregnancy and breast-feeding
During pregnancy and breast-feeding the drug to agree with the doctor.
Cutochnaya dose for pregnant women should not exceed 1500 mg calcium and 600 IU vitamin D3, since hypercalcemia, developing on the background overdose during pregnancy may cause defects mental and physical development of the child.
Breastfeeding women should be aware that Kolekaltsiferol and its metabolites into breast milk. This should be considered when supplemental calcium and vitamin D3 child.
Conditions of supply of pharmacies
Without recipe.
side effects
They were identified following side reactions during the post-registration of the drug. Since the information about such reactions have been reported voluntarily from an unknown number of people, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug administration.
Disorders of the gastrointestinal tract: may cause abdominal pain, constipation, diarrhea, flatulence, nausea and vomiting.
Disorders of immune system: allergic reaction, anaphylactic reaction, anaphylactic shock.
Rare hypersensitivity reaction with the appropriate laboratory and clinical manifestations, including asthmatic syndrome, mild to moderate skin reactions and / or respiratory and / or gastrointestinal and / or cardiovascular system.
Symptoms may include rash, hives, swelling, itching, respiratory distress syndrome and, rarely, severe reactions, including anaphylactic shock.
special instructions
The dose should not exceed specified in instructions as an increased calcium intake can inhibit the intestinal absorption of iron, zinc and other minerals required.
Effects on ability to drive and driving mechanisms:
There are no data on the effect of the drug on the rate of psychomotor reactions when driving and working with the exact mechanisms.
Storage conditions
At a temperature above 25 degrees Celsius.
Keep out of the reach of children.
Dosing and Administration
Ingest during meal time, drinking plenty of water (200 mL).
For adults and children over 12 years old and the elderly:
For the prevention of osteoporosis, calcium deficiency, vitamin D and minerals – 1 tablet 2 times per day.
The average duration – 2 months.
In addition to the specific treatment of osteoporosis, treatment of calcium deficiency, vitamin D and minerals – 1 tablet 2-3 times a day.
The average duration – 3 months.
In situations requiring therapeutic use of calcium supplements, vitamin D and minerals – 1 tablet 1-2 times a day.
The average duration of the course – 4-6 weeks.
The duration of treatment is determined by the individual physician.
Dosage during pregnancy: 1 tablet 1-2 times a day.
Patients with hepatic insufficiency:
No need for dose adjustment.
The maximum daily dose should not exceed 3 tablets.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Calcemin

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