Acyclovir ointment Ch. 3% 5g tuba

Description

Composition
Active substance:
1 g of ointment contains: acyclovir – 0.03 g
Excipients:
Vaseline.
Product form:
Ophthalmic ointment 3%.
3 g, 5 g or laminated aluminum tubes.
Each envelope with instructions for use in a stack of cardboard.
Contraindications
Hypersensitivity to acyclovir or valacyclovir. During breastfeeding.
Dosage
30 mg / g
Indications
Herpetic keratitis is caused by the virus Herpes simplex type 1 or 2.
pharmachologic effect
Pharmacological group:
Antiviral agent for topical administration.
Pharmacodynamics:
Antiviral (antiherpetic) agent – a synthetic nucleoside analogue of thymidine.
In infected cells containing viral thymidine kinase, phosphorylation occurs and conversion to atsiklovirmonofosfat. Influenced atsiklovirmonofosfat guanylate cyclase is converted into the diphosphate and under the action of several cellular enzymes – a triphosphate. The high selectivity of action, and low toxicity to humans due to the lack of the enzyme necessary for the formation atsiklovirtrifosfata in intact microorganism cells.
Atsiklovirtrifosfat embedding into synthesized virus deoxyribonucleic acid (DNA), inhibit virus replication. The specificity and the very high selectivity of action is also advantageous due to its accumulation in cells infected with the herpes virus.
Highly active against Herpes simplex virus types 1 and 2; virus that causes chickenpox and zoster (Varicella zoster); Epstein-Barr virus (types of viruses are listed in ascending order of magnitude of the minimum inhibitory concentration (MIC) of acyclovir). Moderately active against cytomegalovirus (CMV).
When herpes prevents new elements disease, reduces the likelihood of cutaneous dissemination and visceral complications accelerates education crusts, reduces pain in the acute phase of herpes zoster.
Pharmacokinetics:
Acyclovir is readily penetrates through the epithelium of the cornea and creates a therapeutic concentration in the aqueous humor. Currently, there are no methods for determining acyclovir in the blood when administered in the form of an eye ointment. Acyclovir at external application is defined only in the urine, and in small quantities. This concentration has no therapeutic value.
Pregnancy and breast-feeding
Use of the drug during pregnancy is possible in the case if the potential benefit to the mother outweighs the potential risk to the fetus. The drug is found in breast milk after entering the systemic circulation the mother, so the period of treatment should stop breastfeeding.
Conditions of supply of pharmacies
Without recipe.
Storage conditions
At a temperature not exceeding 25 C. Keep out of reach of children.
Dosing and Administration
Locally.
Adults and children eye ointment in the form of a strip 1 cm in length is laid in the lower conjunctival sac 5 times a day (every 4 hours) until healing.
Treatment continued for 3 more days after healing.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist