Acyclovir ointment 5-quinacrine% 10g tuba

$1.07

Acyclovir ointment 5-quinacrine% 10g tuba

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Description

Composition
Active substance:
100 g of ointment contain: Acyclovir in terms of 100% substance 5 g
Excipients:
40 g of propylene glycol, petrolatum 12.5 g liquid paraffin 7.5 g, 5 g of the wax emulsion, macrogol (polyethylene 1500) 1 g Purified water up to 100 g
Description:
Ointments white or nearly white. Presence of characteristic odor.
Product form:
Ointment for external use 5%.
2, 3, 5 or 10 g of aluminum into a tube. Each tube together with instructions for use placed in a pile of cardboard.
Contraindications
Hypersensitivity to acyclovir and other ingredients.
Precautions: Pregnancy, lactation, dehydration, kidney failure.
Dosage
50 mg / g
Indications
Skin infections caused by Herpes simplex virus types 1 and 2, genital herpes, herpes zoster, chickenpox.
Interaction with other drugs
When applied externally revealed no interactions with other drugs. Enhancing observed with concomitant administration of immunostimulants.
pharmachologic effect
Pharmacological group:
Antiviral agent for topical administration.
Pharmacodynamics:
Antiviral drug – a synthetic nucleoside analogue of thymidine. In infected cells containing viral thymidine kinase, phosphorylation occurs and conversion to acyclovir monophosphate. Under the influence of guanylate cyclase is converted into acyclovir monophosphate and diphosphate by the action of several cellular enzymes – a triphosphate.
The high selectivity of action, and low toxicity to humans due to the lack of the enzyme necessary for the formation of acyclovir triphosphate in intact microorganism cells.
Acyclovir triphosphate, “embedding” in the synthesized DNA virus, blocking reproduction of the virus. The specificity and the very high selectivity of action is also advantageous due to its accumulation in cells infected with the herpes virus. Highly active against Herpes simplex virus types 1 and 2; virus that causes chickenpox and zoster (Varicella zoster); Epstein-Barr virus.
Moderately active against cytomegalovirus.
Pharmacokinetics:
When applied to intact skin: absorption minimum; not detected in blood and urine. On the affected skin: moderate absorption; in patients with normal renal function, the serum concentration amounts to 0.28 g / ml, in patients with chronic renal failure (CRF), – to 0.78 ug / ml. Excreted by the kidneys (up to 9.4% of the daily dose).
Pregnancy and breast-feeding
Use of the drug is shown only in those cases where the intended benefits to the mother outweighs the potential risk to the fetus.
During treatment it is necessary to resolve the issue of termination of breastfeeding.
Conditions of supply of pharmacies
Without recipe.
side effects
Congestion, dryness, peeling skin; burning, inflammation in contact with mucous membranes. Perhaps the development of atopic dermatitis.
special instructions
the drug must be used as soon as possible to achieve maximum therapeutic effect (at the first sign of disease: burning, itching, tingling, a feeling of tension and redness). The ointment should not be applied to mucous membranes of the mouth and eyes as well as possible development of pronounced local inflammation. In the treatment of genital herpes should avoid sex or use condoms as well as the application of acyclovir does not prevent transmission of the virus to partners.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. The drug is applied with clean hands or cotton swab 5 times a day (every 4 hours), a thin layer to the affected and bordering them skin. Therapy should continue until such time until the bubbles do not form a crust, or until they are completely healed.
Duration of therapy is an average of 5 days, maximum – 10 days.
In the absence of effect it is necessary to consult a doctor.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

QUINACRINE INN

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