Acyclovir cream naruzhn.prim-I 5% 1 pc 2g ozone

Description

Composition
Active substance:
Acyclovir – 5.00 g
Excipients:
propylene glycol – 40.00 g, poloxamer 407 – 1.00g, glyceryl monostearate 40-55 Type II – 0,75 g,
macrogol 20 stearate type I – 0,75 g, emulsifier №1 – 7,50 g, Dimethicone 100 – 1.00 g Vaseline – 11.50 g, liquid paraffin (vaseline oil) – 5.00 g Water – up 100.0 g
Description:
uniform cream white or nearly white.
Product form:
Cream for external use 5%.
2 g in a tube of aluminum.
Each tube together with instructions for use placed in a cardboard box (pack).
Contraindications
Hypersensitivity to acyclovir and other ingredients.
CAREFULLY
Pregnancy, lactation.
Dosage
50 mg / g
Indications
Skin infections caused by Herpes simplex virus types 1 and 2, including herpes lips.
Interaction with other drugs
When applied externally revealed no interactions with other drugs.
Overdose
Symptoms: (if accidentally swallowed): headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, impairment of renal function.
Treatment: maintenance of vital functions, hemodialysis.
pharmachologic effect
Pharmacological group:
an antiviral agent.
Pharmacodynamics:
Acyclovir is active in vitro against Herpes simplex type 1 and 2 virus, Varicella zoster, Epstein-Barr virus and cytomegalovirus. Thymidine kinase virus-infected cells through a series of sequential reactions actively converts acyclovir to a mono-, di-, and triphosphate of acyclovir. Last interacts with the viral DNA polymerase and incorporated into DNA, which is synthesized for new viruses. Thus, a “defective” viral DNA, which leads to suppression of replication of new generations of viruses.
Pharmacokinetics:
When applied externally substantially not absorbed through the intact skin is not determined in the blood and urine. When applied to the affected skin with a mild suction. In patients with normal renal function, the serum concentration amounts to 0.28 g / ml, in patients with chronic renal insufficiency – up to 0.78 g / ml. Excreted by the kidneys (up to 9.4% of the daily dose).
Pregnancy and breast-feeding
Pregnancy and lactation are used only if the expected benefit to the mother outweighs the potential risk to the fetus and child
Conditions of supply of pharmacies
Without a prescription
side effects
Adverse reactions are presented in accordance with the classification the World Health Organization (WHO) of the frequency depending on the frequency of appearance: very often (> 1/10), often (by> 1/100 to
special instructions
To achieve the maximum therapeutic effect of the drug should be started as soon as possible after the onset of infection (at the first signs of the disease: burning, itching, tingling, a feeling of tension and redness). Cream should not be applied to the mucous membranes of the mouth, eyes, nose, and vagina, as may develop pronounced local inflammation. Patients with compromised immune systems in the treatment of any infectious disease should follow the doctor’s recommendations.
The effect on the ability to operate vehicles, machinery
It has not been studied.
Storage conditions
In the dark place at a temperature not higher than 25 ° C.
Keep out of the reach of children
Dosing and Administration
Outwardly.
Adults. The preparation applied 5 times a day (every 4 hours), a thin layer to the affected and bordering them skin. The cream is applied either with a cotton swab or clean hands, to avoid further infection of affected areas. It is important to start treatment as soon as possible at the beginning of the disease, it is best – during the prodromal period.
Therapy should continue until such time until the bubbles do not form a crust, or until they are completely healed.
Duration of therapy is an average of 5 days and not exceed 10 days.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist