Acyclovir cream mest.i naruzhn.prim I-5% 10g tube vertex

$1.19

Acyclovir cream mest.i naruzhn.prim I-5% 10g tube vertex

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SKU: 01383861736 Categories: , , Tags: ,

Description

Composition
Active substance:
100 g of cream contain: Acyclovir – 5.0 g ;.
Excipients:
100 g of cream contain: Propylene Glycol – 8.0 g; liquid paraffin (vaseline oil) – 12.0 g; Cetyl alcohol – 6.0 g; 6 macrogol cetostearyl ether – 1.5 g; macrogol cetostearyl ether 25 – 1.5 g; methyl parahydroxybenzoate (methyl paraben, Nipagin) – 0.15 g; propyl parahydroxybenzoate (propylparaben, Nipasol) – 0.05 g; Purified water – up to 100.0 g
Description:
Uniform cream white or nearly white.
Product form:
Cream for local and external application of 5%.
2 g, 5 g or 10 g aluminum tubes.
Each tube together with instructions for use in a pile of cardboard.
Contraindications
Hypersensitivity to any component of the formulation.
Dosage
50 mg / g
Indications
Simple herpes skin and mucous membranes, genital herpes (primary and recurrent); localized zoster (adjuvant therapy).
Interaction with other drugs
Enhancing observed with concomitant administration of immunostimulants.
Overdose
Symptoms (if accidentally swallowed): headache, neurological disorders, shortness of breath, nausea, vomiting, diarrhea, impairment of renal function.
Treatment: maintenance of vital functions, hemodialysis.
pharmachologic effect
Pharmacological group:
Antiviral agent for topical administration.
Pharmacodynamics:
Antiviral drug – a synthetic nucleoside analogue of thymidine. In infected cells containing viral thymidine kinase, phosphorylation occurs and conversion to atsiklovirmonofosfat. Under the influence of guanylate cyclase is converted into atsiklovirmonofosfat atsiklovirdifosfat and under the action of several cellular enzymes – in atsiklovirtrifosfat. The high selectivity of action, and low toxicity to humans due to the lack of the enzyme necessary for the formation atsiklovirtrifosfata in intact microorganism cells.
Atsiklovirtrifosfat “embedding” in the synthesized virus deoxyribonucleic acid (DNA), inhibit virus replication. The specificity and the very high selectivity of action is also advantageous due to its accumulation in cells infected with the herpes virus. Highly active against Herpes simplex virus types 1 and 2; virus that causes chickenpox and zoster (Varicella zoster); Epstein-Barr virus (types of viruses are listed in ascending order of magnitude of the minimum inhibitory concentration (MIC) of acyclovir). Moderately active against cytomegalovirus (CMV).
When herpes prevents new elements disease, reduces the likelihood of cutaneous dissemination and visceral complications accelerates education crusts, reduces pain in the acute phase of herpes zoster.
Pharmacokinetics:
In the application of cream to the intact skin: absorption minimum; not detected in blood and urine. Affected skin: moderate absorption; in patients with normal renal function, the serum concentration amounts to 0.28 g / ml, in patients with chronic renal insufficiency – up to 0.78 g / ml. Excreted by the kidneys (up to 9.4% of the daily dose).
Pregnancy and breast-feeding
Pregnant women and women during the period of breast-feeding is recommended to use the drug only when the application of the benefit to the mother outweighs the potential risk to the fetus / baby.
Conditions of supply of pharmacies
Without a prescription.
side effects
Hyperemia, burning sensation, pain, itching, skin rash, vulva at the site of application. May develop allergic reactions.
Post-marketing experience: swelling at the site of application.
special instructions
Be used with caution during pregnancy and lactation.
Cream should not be applied to the mucous membranes of the mouth and eyes.
The effectiveness of the treatment will be higher than before treatment began (at the first sign of infection).
Acyclovir does not prevent the transmission of sexually transmitted herpes, so the period of treatment should refrain from sexual intercourse, even in the absence of clinical manifestations.
For realization of the therapeutic effect of acyclovir is set to the state of the immune system. For patients with reduced immunity (HIV / AIDS, or after bone marrow transplantation) should consult a physician, since background topical acyclovir cream should be administered systemic administration of the drug, as well as in the case of heavy flows and recurrent herpes infection.
The effect on the ability of control of vehicles and mechanisms
No data.
Storage conditions
In a dry place at a temperature not higher than 25 ° C.
Keep out of the reach of children.
Dosing and Administration
Outwardly. Locally.
Acyclovir cream is applied in a thin layer (about 1.25 cm strips of 25 cm2 cream on the affected skin) on the affected areas 4 – 6 times a day. It is important to start treatment as soon as possible at the beginning of the disease, it is best – during the prodromal period.
The cream is applied either with a cotton swab or clean hands, to avoid further infection of affected areas.
Duration of treatment – not less than 5 days, a maximum of 10 days.
If the symptoms do not disappear after 10 days of treatment, the patient should seek medical advice.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

VERTEX

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