Acyclovir 400mg forte Table 20 pc

$5.07

Acyclovir 400mg forte Table 20 pc

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Description

Composition
Active substance:
1 tablet contains: acyclovir – 400 mg.
Excipients:
Potato starch, lactose (milk sugar), povidone, sugar (sucrose), sodium lauryl sulfate, magnesium stearate.
Description:
Tablets of white color, biconcave, oblong shape with rounded ends, with the mark on one side.
Product form:
Tablets of 400 mg.
At 5, 10, 12, 15, 20 or 30 tablets in blisters.
1, 2 or 3 blisters with instructions for use placed in a pile of cardboard.
Contraindications
Increased sensitivity to acyclovir, ganciclovir or any excipient the formulation.
The drug is contraindicated during lactation.
Children under 3 years of age (for a given dosage form).
Galactose intolerance, lactase deficiency, glucose-galactose malabsorption.
Precautions: Pregnancy; the elderly and patients receiving high doses, especially against the background of dehydration; impaired renal function; neurological disorders or neurological response to reception of cytotoxic drugs (including history).
Dosage
400 mg
Indications
Treatment of infections of the skin and mucous membranes caused by Herpes simplex viruses types I and II, both primary and secondary, including genital herpes.
Prophylaxis of recurrent exacerbations, infections caused by Herpes simplex viruses types I and II, in patients with normal immune status.
Prevention of primary and recurrent infections caused by Herpes simplex viruses types I and II in patients with immunodeficiency.
In the complex treatment of patients with severe immunodeficiency: HIV infection (AIDS stage, the early clinical manifestations and detailed clinical picture) and in patients undergoing bone marrow transplantation.
Treatment of primary and recurrent infections caused by virus Varicella zoster (chickenpox and shingles – Herpes zoster).
Interaction with other drugs
The simultaneous use of probenecid leads to an increase in the average half-life and reduced clearance of acyclovir.
When concomitantly with nephrotoxic drugs increases the risk of renal dysfunction.
Enhancing observed with concomitant administration of immunostimulants.
Overdose
No cases of overdose of acyclovir after oral administration.
pharmachologic effect
Pharmacological group:
Antiviral drug.
Pharmacological properties:
The antiviral drug, a synthetic analogue of the acyclic purine nucleoside having a high selective effect on herpes viruses. Inside the infected by the action of the viral thymidine kinase cell passes through a series of successive transformation reactions acyclovir in mono-, di-, and triphosphate of acyclovir. Acyclovir-triphosphate and incorporated into viral DNA chain and blocks its synthesis by competitive inhibition of viral DNA polymerase.
In vitro acyclovir effective against herpes simplex virus – Herpes simplex type I and II, against the virus Varicella zoster; higher concentrations are required to inhibit the Epstein-Barr virus.
Pharmacokinetics:
The ingestion bioavailability is 15-30%. Acyclovir well penetrates into all organs and tissues of the body, including the brain and skin. Binding to plasma proteins is 9-33% and is independent of its concentration in plasma. in the cerebrospinal fluid concentration is about 50% of its concentration in plasma. Acyclovir crosses the placental barrier and accumulate in the breast milk. The maximum concentration after administration into 200 mg 5 times per day – 0.7 pg / ml, time to maximum concentration – 1.5-2 hours.
It is metabolized in the liver to pharmacologically inactive form compound 9 karboksimetoksimetilguanina. The half-life in adults with normal renal function is 2-3 hours. In patients with severe renal failure half-life – 20 hours of the hemodialysis – 5.7 hour (with up to 60% of the initial value of acyclovir plasma concentration decreases). About 84% excreted by the kidneys in unchanged form and 14% – in the form of a metabolite. Renal clearance of acyclovir is 75-80% of total plasmatic clearance. Less than 2% acyclovir excreted through the intestines.
Pregnancy and breast-feeding
Acyclovir crosses the placental barrier and accumulate in the breast milk.
Use during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, acyclovir lactation requires interrupt breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
The drug is generally well tolerated.
On the part of the gastrointestinal tract: in rare cases – abdominal pain, nausea, vomiting, diarrhea.
In the blood: transient slight increase in liver enzymes, rarely – a slight increase in levels of urea and creatinine, hyperbilirubinemia, leukopenia, erythropenia.
Central nervous system: rarely – headache; weakness; in some cases, tremors, dizziness, fatigue, exhaustion, drowsiness, insomnia, paresthesia, confusion, hallucinations, decreased concentration, agitation.
Allergic reactions: anaphylactic reactions, skin rash, pruritus, Lyell syndrome, urticaria, erythema multiforme, including Stevens-Johnson syndrome, fever.
Other: rare – alopecia, peripheric edema, blurred vision, lymphadenopathy, myalgia, malaise.
special instructions
Apply strictly prescribed by a doctor to avoid complications in adults and children older than 3 years.
Precautions prescribed to patients with impaired renal function, elderly patients due to the increase in half-life of acyclovir.
In applying the drug to provide a sufficient amount of liquid.
Before the drug should monitor renal function (blood urea level and plasma creatinine).
Acyclovir does not prevent the transmission of sexually transmitted herpes, so the period of treatment should refrain from sexual intercourse, even in the absence of clinical manifestations.
Due to the presence of lactose, patients with rare hereditary disorders such as galactose intolerance, lactase deficiency, glucose-galactose malabsorption should not take the drug.
Storage conditions
In a dry, dark place at a temperature not higher than 25 C. Keep out of reach of children.
Dosing and Administration
Inside. The drug is taken during or immediately after meals and drink plenty of water.
The batch is individually depending on the severity of the disease.
In treating infections of the skin and mucous membranes caused by Herpes simplex types I and II:
Adults: drug prescribed 200 mg 5 times per day for 5 days with 4 hour intervals during the day and with an 8-hour intervals over night. In more severe cases, treatment may be extended by doctor’s prescription to 10 days. In the combined therapy in patients with severe immunodeficiency, including the developed clinical picture of HIV infection (including early clinical manifestations of HIV infection and AIDS step) after the bone marrow implanted administered 400 mg 5 times per day.
For the prevention of recurrence of infections caused by viruses Herpessimplex type I and II, in patients with normal immune status and disease relapse prescribed 200 mg 4 times a day every 6 hours duration of the course of 6 to 12 months.
For prevention of infections caused by viruses Herpessimplex type I and II, immunocompromised adults, the drug is recommended to appoint 200 mg 4 times a day, every 6 hours maximum dose – 400 mg acyclovir five times per day depending on the severity of the infection.
Children: to infection by Herpessimplexi prevention of infections in patients with weakened immune defenses, children over 3 years of age receive the same dose as adults.
In the treatment of infections caused by Varicella zoster:
Adults: preparation is prescribed 800 mg 5 times a day every 4 hours during the day and 8 hour intervals for a night. The duration of treatment 7-10 days.
Children: varicella administered 20 mg / kg 4 times a day for 5 days (maximum single dose 800 mg) for children from 3 to 6 years: 400 mg 4 times a day, over 6 years: 800 mg 4 times a day for 5 days.
In the treatment of infections caused by Herpes zoster, adults appoint 800 mg 4 times a day every 6 hours for 5 days.
In patients with impaired renal function:
In the treatment and prevention of infections caused by Herpes simplex, in patients with a creatinine clearance less than 10 mL / min, the dosage of the drug should be reduced to 200 mg two times a day at 12 hour intervals.
In the treatment of infections caused by Varicella zoster, in patients with a creatinine clearance less than 10 mL / min is recommended to reduce the dosage of the drug to 800 mg 2 times a day with 12-hour intervals; when creatinine clearance up to 25 ml / min is assigned by 800 mg three times a day at 8-hour intervals.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist

Additional information

Weight0.100 kg
Manufacturer

Obolensky

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