Acyclovir 200mg, quinacrine Table 20 pc

Description

Composition
Active substance:
Acyclovir in terms of 100% substance – 200 mg and 400 mg.
Excipients:
Cellulose microcrystalline 21.46 mg or 42.92 mg, povidone 1.17 mg, or 2.34 mg magnesium stearate 2 mg or 4 mg, indigo carmine 0.1 mg or 0.2 mg Sodium carboxymethyl starch 12.5 mg or 25 mg purified water 12.77 mg or 25.54 mg, respectively.
Description:
Tablets with dark blue and light blue highlights and a possible white spots, Valium, with a facet and Valium.
Product form:
Tablets of 200 mg and 400 mg. 10 tablets in blisters. 2 blisters together with instructions for use in a stack of cardboard.
Contraindications
Hypersensitivity to acyclovir, ganciclovir, valacyclovir, or components of the drug, lactation, children under 3 years.
Carefully
Pregnancy, older age, dehydration, renal failure, neurological disorders or neurological response to reception of cytotoxic drugs (including history). Pregnancy and lactation Use during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus. If necessary, use during lactation should stop breastfeeding.
Dosage
200 mg
Indications
-treatment infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2, both primary and secondary, including genital herpes, -profilaktika exacerbation of recurrent infections caused by Herpes simplex virus types 1 and 2 in patients with normal immune status, – prophylaxis of primary and recurrent infections caused by Herpes simplex virus types 1 and 2, in immunocompromised patients, -to the complex therapy for patients with severe immunodeficiency in HIV infection (AIDS stage, early clinical manifestations and deployed to inicheskaya picture) and in patients undergoing bone marrow transplantation, -treatment of primary and recurrent infections caused by the virus Varicella zoster (chickenpox, shingles).
Interaction with other drugs
In an application with Probenecid increases the average half-life and reduced clearance of acyclovir.
While the use of nephrotoxic drugs increases the risk of renal dysfunction.
Overdose
Symptoms: agitation, coma, convulsions, lethargy. Possible precipitation of acyclovir in the renal tubules, if the concentration exceeds its solubility in the renal tubules (2.5 mg / ml).
Treatment: symptomatic.
pharmachologic effect
Pharmacodynamics:
Antiviral drug – a synthetic purine nucleoside analogue acyclic possessing high selective effect on herpes viruses. In infected cells containing viral thymidine kinase, phosphorylation occurs and conversion to acyclovir monophosphate. Under the influence of guanylate cyclase is converted into acyclovir monophosphate and diphosphate by the action of several cellular enzymes – a triphosphate.
Acyclovir triphosphate is incorporated into the viral DNA chain, and blocking its synthesis by competitor-Nogo inhibition of viral DNA polymerase. The specificity and the very high selectivity of action is also advantageous due to its accumulation in cells infected with the herpes virus.
Highly active against Herpes simplex virus types 1 and 2; virus that causes chickenpox and zoster (Varicella zoster); Epstein-Barr virus. Moderately active against tsitomegalo- virus.
When herpes prevents new elements disease, reduces the likelihood of skin dissemi- nation and visceral complications, accelerates the formation of crusts and reduces pain in the acute phase of herpes zoster.
Pharmacokinetics:
The ingestion bioavailability is 15-30%. Acyclovir well penetrates all organs and tissues of the body, the concentration in the cerebrospinal fluid – 50% of its concentration in plasma. It penetrates the blood-brain and placental barriers, accumulates in breast milk. Relationship to plasma proteins – 9-33%. The maximum concentration (Cmax) in plasma after oral administration of 200 mg 5 times per day – 0.7 pg / ml. . The time to reach maximum concentration in the blood plasma of 1.5-2 hours is metabolized in the liver to produce pharmacologically inactive metabolite – 9 karboksimetoksimetilguanina. The half-life (T1 / 2) ingestion -. 2-3 hours in patients with severe renal insufficiency T1 / 2 – 20 hours, the hemodialysis – 5.7 hours (the plasma concentration of acyclovir is reduced to 60% of the initial value ). Excreted by the kidneys in unchanged form (about 84%) in the form of a metabolite (approximately 14%). Less than 2% is excreted through the gastrointestinal tract, trace amounts determined in the exhaled air.
Pregnancy and breast-feeding
Use during pregnancy is possible only when the intended benefits to the mother outweighs the potential risk to the fetus.
If necessary, use during lactation should stop breastfeeding.
Conditions of supply of pharmacies
On prescription.
side effects
From the digestive system: nausea, vomiting, diarrhea, abdominal pain; rarely – reversible increases in bilirubin and activity of “liver” enzymes.
From hemopoiesis system: very rarely – anemia, leukopenia, thrombocytopenia.
From the urinary system: rarely – elevated levels of urea and creatinine in the blood; very rarely – acute renal failure.
Central nervous system: headache, weakness, dizziness, fatigue, confusion, hallucinations, drowsiness, paresthesia, seizures, decreased concentration tion of attention, agitation.
Allergic reactions include itching, rash, Lyell syndrome, urticaria, erythema multiforme, including Stevens-Johnson Syndrome, angioneurotic edema, anaphylaxis.
Other: fever, lymphadenopathy, peripheral edema, blurred vision, myalgia, alopecia.
special instructions
Before the drug should monitor renal function (blood urea content and plasma creatinine).
In applying the drug to provide a sufficient amount of liquid.
Prolonged or repeated treatment with acyclovir patients with reduced immunity could lead to the emergence of strains of viruses, sensitive to its action. The majority of dedicated virus strains that are insensitive to acyclovir, found a relative lack of viral thymidine kinase; strains were isolated with altered with altered thymidine kinase or DNA polymerase. In vitro effect of acyclovir on isolated strains of Herpes simplex virus can cause GOVERNMENTAL less sensitive strains.
Acyclovir does not prevent the transmission of sexually transmitted herpes, so the period of treatment should refrain from sexual intercourse, even in the absence of clinical manifestations.
During the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.
Storage conditions
In a dry, dark place at a temperature not higher than 25 ° C. Keep out of the reach of children.
Dosing and Administration
Inside, during or immediately after a meal, drink plenty of water.
The mode set individually depending on the severity of the disease.
In treating infections of the skin and mucous membranes caused by Herpes simplex virus types 1 and 2
Adults – 200 mg 5 times per day (every 4 hours during waking hours, except for the night sleep) for 5 days to treat genital herpes – 10 days, as appropriate treatment duration may be prolonged.
In the combined therapy in patients with severe immunodeficiency, including the developed clinical picture of HIV infection (including early clinical manifestations of HIV infection and AIDS step) after the bone marrow implanted administered 400 mg 5 times per day.
For the prevention of recurrence of infections caused by the Herpes simplex virus 1 and type 2 patients with normal immune status
Adults – 200 mg four times a day every 6 hours duration of the course of 6 to 12 months.
For the prevention of infections caused by Herpes simplex virus types 1 and 2, in immunocompromised patients
Adults – 200 mg four times a day every 6 hours maximum dose – 400 mg 5 times per day in dependence bridge severity of the infection.
In the treatment of herpes zoster – 800 mg 5 times per day (every 4 hours during waking hours, for excluded cheniem-night sleep) for 7-10 days.
Children under the age of 3 years, the drug is administered in the same dose as adults.
Treatment of varicella: adults and children older than 6 years – 800 mg 4 times daily; children 3-6 years – 400 mg 4 times a day. More precisely, the dose can be determined from the rate of 20 mg / kg.
Kurslecheniya – 5 days.
Patients with impaired renal function required doses and dosing regimen correction in dependence on the magnitude of the clearance of creatinine and type of infection. For the treatment of infection by Herpes simplex, with creatinine clearance less than 10 mL / min daily dose should be reduced to 400 mg, dividing it into 2 doses (with intervals therebetween of at least 12 hours, i.e. 200 mg 2 times a day).
In the treatment of infections caused by Varicella zoster, and maintenance treatment of patients with severe immunodeficiency – patients with a creatinine clearance of 10-25 ml / min prescribers 800 mg three times a day at intervals of 8 hours, with creatinine clearance less than 10 mL / min – 800 mg 2 times a day at intervals of 12 hours.
Information
Appearance may differ from that depicted in the picture. There are contraindications. You need to read the manual or consult with a specialist